Human Vitamin D Receptor (VDR) Protein
247€ (10 µg)
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935106861
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name
Human Vitamin D Receptor (VDR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652096
tested applications
WB, SDS-PAGE
Description
Vitamin D Receptor (VDR) Protein is a Recombinant protein from Human.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Vitamin D Receptor (VDR) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 21.6 kDa Observed MW (SDS-PAGE): 20 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met272-Ser427 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11473 |
| Alias | NR1I1,PPP1R163,Vitamin D3 receptor,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1 |
| Background | Protein VDR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Vitamin D receptor (VDR) is a nuclear receptor that mediates the effects of vitamin D, a crucial nutrient involved in calcium and phosphate homeostasis, bone health, immune function, and cellular growth VDR is activated upon binding to the active form of vitamin D, calcitriol, which allows it to regulate gene expression by binding to vitamin D response elements (VDREs) in target genes VDR is involved in regulating calcium absorption in the intestine, bone mineralization, and the modulation of immune responses, particularly in regulating inflammation and the function of T cells It also plays a role in the prevention of certain cancers, cardiovascular diseases, and autoimmune disorders Dysregulation of VDR activity has been linked to diseases such as osteoporosis, rickets, cardiovascular disease, and cancer In addition, VDR is a target for therapies aimed at managing conditions related to vitamin D deficiency, autoimmune diseases, and bone disorders
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