Human Vascular Endothelial Growth Factor receptor-3 Fc Chimera (FLT4 Fc) Enzyme

Este producto es parte de FLT4 -  fms related receptor tyrosine kinase 4
Product Graph
234€ (2 µg)

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935106861
info@markelab.com
name
Human Vascular Endothelial Growth Factor receptor-3 Fc Chimera (FLT4 Fc) Enzyme
category
Proteins and Peptides
provider
Abbexa
reference
abx073670
tested applications
SDS-PAGE

Description

Vascular Endothelial Growth Factor receptor-3 Fc Chimera Protein is a recombinant protein kinases.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Vascular Endothelial Growth Factor receptor-3 Fc Chimera (FLT4 Fc)
Host
Insect
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Origin
Human
Expression
Recombinant
Purity
> 90% (SDS-PAGE and RP-HPLC)
Size 1
2 µg
Size 2
10 µg
Size 3
1 mg
Form
Lyophilized
Tested Applications
SDS-PAGE
Availability
Shipped within 5-10 working days.
Dry Ice
No
UniProt ID
P35916
Alias
PCL,CHTD7,FLT-4,FLT41,LMPH1A,LMPHM1,VEGFR3,VEGFR-3,Tyrosine-protein kinase receptor FLT4,Fms-like tyrosine kinase 4,Vascular endothelial growth factor receptor 3
Background
Protein FLT4
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Fms related receptor tyrosine kinase 4 (FLT4) FLT4, also known as vascular endothelial growth factor receptor 3 (VEGFR3), is a receptor tyrosine kinase critical for the regulation of lymphangiogenesis, the formation of lymphatic vessels. Structurally, FLT4 comprises an extracellular domain with seven immunoglobulin-like loops, a single transmembrane domain, and an intracellular tyrosine kinase domain. FLT4 binds VEGF-C and VEGF-D ligands, leading to receptor dimerization and activation of downstream signaling pathways, including the MAPK and PI3K-AKT cascades. These pathways are essential for lymphatic endothelial cell proliferation, migration, and survival. FLT4 is predominantly expressed in lymphatic endothelial cells, where it plays a pivotal role in maintaining lymphatic vessel integrity and fluid homeostasis. Dysregulation of FLT4 has been linked to lymphedema, a condition characterized by lymphatic fluid accumulation, and its overexpression has been implicated in cancer progression, where it promotes tumor lymphangiogenesis and metastasis. FLT4 is a promising therapeutic target for modulating lymphatic function in both pathological and developmental contexts.

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