Human Vascular Endothelial Growth Factor receptor-2 Fc Chimera (VEGFR2 Fc) Enzyme
234€ (2 µg)
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Name
Human Vascular Endothelial Growth Factor receptor-2 Fc Chimera (VEGFR2 Fc) Enzyme
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073669
Tested Applications
SDS-PAGE
Description
Human Vascular Endothelial Growth Factor receptor-2 Fc Chimera Protein is a recombinant protein kinase expressed in Insect cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Vascular Endothelial Growth Factor receptor-2 Fc Chimera (VEGFR2 Fc) |
| Host | Insect |
| Assay Type | Biological Activity: Inhibits the VEGF-dependent proliferation of Human umbilical vein endothelial cells. Sequence Fragment: 968 AA. The soluble receptor protein contains only the first 7 extracellular domains, which is sufficient for ligand binding. Tag: Recombinant Human Soluble VEGFR2 is fused with the Fc domain of Human IgG1. |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Observed MW | 145 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 1X PBS, pH 7.2. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store dessicated at -20 °C for long-term storage. Upon reconstitution, store at 4°C for up to 7 days and store below -18°C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35968 |
| Alias | FLK1,CD309,VEGFR,VEGFR2,VEGFR-2,Protein-tyrosine kinase receptor flk-1,Fetal liver kinase 1,Vascular endothelial growth factor receptor 2 |
| Background | Protein KDR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile water to a concentration of at least 50 µg/ml. This stock solution can be further diluted if required. Concentration: Prior to lyophilization: 1 mg/ml |
Background
KDR, also known as vascular endothelial growth factor receptor 2 (VEGFR-2), is a critical protein in the regulation of angiogenesis and vascular development. This receptor tyrosine kinase (RTK) is encoded by the KDR gene located on chromosome 4q12 in humans. KDR is a member of the VEGF receptor family, which plays an essential role in the processes of vasculogenesis and angiogenesis by mediating the cellular responses to the vascular endothelial growth factor (VEGF). The VEGF family consists of several ligands, with VEGF-A being the primary ligand for KDR. KDR is predominantly expressed in endothelial cells, where it regulates vascular permeability, endothelial cell proliferation, migration, and survival. Due to its pivotal role in vascular biology, KDR has been extensively studied in the context of cancer, where angiogenesis is a crucial process for tumor growth and metastasis. KDR's involvement in pathological angiogenesis makes it a significant target for anti-angiogenic therapies in cancer treatment. Moreover, it has implications in other diseases characterized by abnormal vascular growth, such as age-related macular degeneration and rheumatoid arthritis.
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