Human Vascular Endothelial Growth Factor receptor-2 Fc Chimera (VEGFR2 Fc) Enzyme
234€ (2 µg)
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935106861
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name
Human Vascular Endothelial Growth Factor receptor-2 Fc Chimera (VEGFR2 Fc) Enzyme
category
Proteins and Peptides
provider
Abbexa
reference
abx073669
tested applications
SDS-PAGE
Description
Human Vascular Endothelial Growth Factor receptor-2 Fc Chimera Protein is a recombinant protein kinase expressed in Insect cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Vascular Endothelial Growth Factor receptor-2 Fc Chimera (VEGFR2 Fc) |
| Host | Insect |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Observed MW | Molecular Weight: 145 kDa Concentration: Prior to lyophilization: 1 mg/ml Sequence Fragment: 968 AA. The soluble receptor protein contains only the first 7 extracellular domains, which is sufficient for ligand binding. Tag: Recombinant Human Soluble VEGFR2 is fused with the Fc domain of Human IgG1. Validity: Stable at room temperature for up to 3 weeks. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Lyophilized Reconstitute in sterile water to a concentration of at least 50 µg/ml. This stock solution can be further diluted if required. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 1X PBS, pH 7.2. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store dessicated at -20 °C for long-term storage. Upon reconstitution, store at 4 °C for up to 7 days and store below -18 °C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35968 |
| Alias | FLK1,CD309,VEGFR,VEGFR2,VEGFR-2,Protein-tyrosine kinase receptor flk-1,Fetal liver kinase 1,Vascular endothelial growth factor receptor 2 |
| Background | Protein KDR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KDR, also known as vascular endothelial growth factor receptor 2 (VEGFR-2), is a critical protein in the regulation of angiogenesis and vascular development. This receptor tyrosine kinase (RTK) is encoded by the KDR gene located on chromosome 4q12 in humans. KDR is a member of the VEGF receptor family, which plays an essential role in the processes of vasculogenesis and angiogenesis by mediating the cellular responses to the vascular endothelial growth factor (VEGF). The VEGF family consists of several ligands, with VEGF-A being the primary ligand for KDR. KDR is predominantly expressed in endothelial cells, where it regulates vascular permeability, endothelial cell proliferation, migration, and survival. Due to its pivotal role in vascular biology, KDR has been extensively studied in the context of cancer, where angiogenesis is a crucial process for tumor growth and metastasis. KDR's involvement in pathological angiogenesis makes it a significant target for anti-angiogenic therapies in cancer treatment. Moreover, it has implications in other diseases characterized by abnormal vascular growth, such as age-related macular degeneration and rheumatoid arthritis.
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