Human Uromodulin (UMOD) Protein

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234€ (2 µg)

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935106861
info@markelab.com
name
Human Uromodulin (UMOD) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx073760
tested applications
SDS-PAGE

Description

Human Uromodulin (UMOD) Protein isolated from human urine.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Uromodulin (UMOD)
Host
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Origin
Human
Observed MW
Molecular Weight: 64.25 kDa (excluding glycosylatation)

Concentration: Prior to lyophilization: 0.6 mg/ml

Sequence Fragment: 590 AA.
Purity
> 95% (SDS-PAGE)
Purification
Filtered (0.4 µm) prior to lyophilization.
Size 1
2 µg
Size 2
10 µg
Size 3
1 mg
Form
Lyophilized Reconstitute in deionized water to a concentration of approximately 0.5 mg/ml. Ensure that the product is fully dissolved before use. Please note that this product is not sterile; filtration using an appropriate sterile filter should be carried out before using the product in cell culture.
Tested Applications
SDS-PAGE
Buffer
Not applicable.
Availability
Shipped within 5-10 working days.
Storage
Stable at room temperature for up to 3 weeks. Store dessicated below -18 °C. After reconstitution, store at 4 °C for up to 7 days or store below -18 °C for long-term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P07911
Gene ID
7369
OMIM
162000
Background
Protein UMOD
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

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Uromodulin, also known as THP(Tamm-Horsfall glycoprotein), is the most abundant protein excreted in the urine under physiological conditions. Uromodulin is synthesized by kidney and localizes in cells lining the ascending limb of Henle and distal convoluted tubule. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases.(PMID: 21654721)

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