Human Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
562.5€ (96 tests)
Elisa Kits UCHL1
proveedor
Abbexareference
abx251226Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Ubiquitin Carboxyl Terminal Hydrolase L1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
Características del producto
category
ELISA Kits
immunogen target
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1)
reactivity
Human
test range
78 pg/ml - 5000 pg/ml
sensitivity
46.9 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
UCHL1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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