Human Tyrosine-Protein Kinase ABL1 (ABL1) Protein (Active)
780€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Tyrosine-Protein Kinase ABL1 (ABL1) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx693110
Tested Applications
SDS-PAGE
Description
Tyrosine-Protein Kinase ABL1 (ABL1) protein is a recombinant Human protein expressed in Insect.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Tyrosine-Protein Kinase ABL1 (ABL1) |
| Host | Insect |
| Assay Type | Activity: Active Sequence Fragment: Pro137-Ser554 Tag: N-terminal GST tag |
| Origin | Human |
| Observed MW | 74 kDa |
| Expression | Recombinant |
| Purity | > 75% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM EDTA, 0.5 mM Reduced Glutathione, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. Shelf Life: 6 months. |
| Dry Ice | No |
| UniProt ID | P00519 |
| Gene ID | 25 |
| NCBI Accession | NP_009297.2 |
| OMIM | 189980 |
| Alias | ABL,BCR-ABL,CHDSKM,ABL proto-oncogene 1 non-receptor tyrosine kinase |
| Background | Protein ABL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
ABL1 is a non-receptor tyrosine kinase involved in various cellular processes, including cytoskeletal remodeling, cell migration, DNA damage response, and signal transduction. It is ubiquitously expressed and localized in both the nucleus and cytoplasm, where it interacts with numerous signaling proteins. ABL1 contains SH2 and SH3 domains, a kinase domain, and regulatory regions that facilitate its interaction with other proteins and its activation in response to cellular stimuli. Dysregulation of ABL1, particularly through chromosomal translocations such as the Philadelphia chromosome, results in the BCR-ABL1 fusion protein, which drives chronic myeloid leukemia (CML) by promoting uncontrolled cell proliferation and survival. Targeting ABL1 with tyrosine kinase inhibitors, such as imatinib, has revolutionized the treatment of CML and highlighted its role as a key therapeutic target. Beyond cancer, ABL1 contributes to cellular responses to oxidative stress, DNA damage repair, and cytoskeletal dynamics, underscoring its importance in maintaining cellular homeostasis and responding to environmental challenges.
Productos relacionados
ABL1 (pY245) Antibody
ABL1 (pY245) Antibody is a Rabbit Polyclonal antibody against ABL1 (pY245). The ABL1 protooncogene encodes a cytoplasmic…
Ver producto
ABL1 (pY412) Antibody
ABL1 (pY412) Antibody is a Rabbit Polyclonal antibody against ABL1 (pY412). The ABL1 protooncogene encodes a cytoplasmic…
Ver producto
Tyrosine-Protein Kinase ABL1 (ABL1) Antibody
Tyrosine-Protein Kinase ABL1 (ABL1) Antibody is a Rabbit Polyclonal antibody against Tyrosine-Protein Kinase ABL1 (ABL1)…
Ver producto