Human Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8) Protein
208€ (10 µg)
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935106861
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name
Human Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691145
tested applications
SDS-PAGE
Description
Human CD30 Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Tumor necrosis factor receptor superfamily member 8 is produced by our Mammalian expression system and the target gene encoding Phe19-Lys379 is expressed with a Fc tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD30 |
| Host | Human |
| Origin | Human |
| Observed MW | Molecular Weight: 65.2 kDa Sequence Fragment: Phe19-Lys379 Tag: C-terminal Fc tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM PB, 150mMNaCl, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | P28908 |
| Alias | CD30,Ki-1,D1S166E,CD30L receptor,Lymphocyte activation antigen CD30,Tumor necrosis factor receptor superfamily member 8 |
| Background | Protein TNFRSF8 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily Member 8), also known as CD30, is a cell surface receptor belonging to the tumor necrosis factor receptor (TNFR) superfamily. This family is composed of receptors that play critical roles in modulating immune responses, inflammation, and apoptosis. CD30 is primarily expressed on activated T and B cells, and its expression is upregulated in certain immune-related diseases and cancers, particularly Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL). It has emerged as a significant target in cancer immunotherapy and as a diagnostic marker for lymphoma. The receptor is a hallmark of classical Hodgkin lymphoma (cHL) and ALCL due to its overexpression on malignant cells. Beyond cancer, CD30 has implications in the regulation of immune homeostasis, playing a role in T-cell activation, differentiation, and proliferation. Dysregulation of CD30 signaling can lead to chronic inflammation and the development of autoimmune disorders, making it an essential molecule of interest in both oncology and immunology.
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