Human Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) Protein

Este producto es parte de TNFRSF12A - TNF receptor superfamily member 12A
Human Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) Protein
780€ (50 µg)

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Name
Human Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx651455
Tested Applications
WB, SDS-PAGE

Description

Human Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Protein (Active) is an active protein from Human Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A).

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A)
Host
E. coli
Assay Type
Activity: Active
Sequence Fragment: Ser24-Ala126
Tag: N-terminal His tag and GST tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 40.8 kDa  Observed MW: 44 kDa
Expression
Recombinant
Purity
> 80%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q9NP84
Gene ID
51330
Alias
Tumor necrosis factor receptor superfamily member 12A,FN14,CD266,TWEAKR,Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14)
Background
Protein TNFRSF12A
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

TNFRSF12A, also known as FN14 (Fibroblast Growth Factor Inducible 14), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). This receptor is highly responsive to cellular stress signals, tissue damage, and inflammation, and it plays an essential role in tissue remodeling, inflammation, and wound healing. FN14 is particularly notable for its role as the primary receptor for TWEAK (TNF-like weak inducer of apoptosis), a member of the TNF superfamily of ligands. The binding of TWEAK to TNFRSF12A activates various downstream signaling pathways that influence processes including cell survival, proliferation, migration, and apoptosis. Its expression is typically low in most normal tissues but is upregulated under stress conditions such as injury, inflammation, or exposure to growth factors. Elevated levels of TNFRSF12A have been observed in a variety of pathological conditions, particularly in inflammatory diseases, cancer, cardiovascular disease, and fibrosis, where its activity is often associated with promoting cell survival, angiogenesis, and tissue remodeling.

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