935106861
info@markelab.com
Precio
225€ (10 µg)
Human Tumor Necrosis Factor Receptor Superfamily, Member 12A Protein is a recombinant Human protein expressed in E. coli. This protein is the immunogen for the following antibodies: abx128013
TNFRSF12A, also known as FN14 (Fibroblast Growth Factor Inducible 14), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). This receptor is highly responsive to cellular stress signals, tissue damage, and inflammation, and it plays an essential role in tissue remodeling, inflammation, and wound healing. FN14 is particularly notable for its role as the primary receptor for TWEAK (TNF-like weak inducer of apoptosis), a member of the TNF superfamily of ligands. The binding of TWEAK to TNFRSF12A activates various downstream signaling pathways that influence processes including cell survival, proliferation, migration, and apoptosis. Its expression is typically low in most normal tissues but is upregulated under stress conditions such as injury, inflammation, or exposure to growth factors. Elevated levels of TNFRSF12A have been observed in a variety of pathological conditions, particularly in inflammatory diseases, cancer, cardiovascular disease, and fibrosis, where its activity is often associated with promoting cell survival, angiogenesis, and tissue remodeling.
Proteins and Peptides
Human
E. coli
Tumor Necrosis Factor Receptor Superfamily Member 12A / TWEAKR (TNFRSF12A)
E. coli
Unconjugated
Lyophilized
WB, SDS-PAGE
10 µg
50 µg
100 µg
200 µg
1 mg
Recombinant
> 95%
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
TNFRSF12A
No
Shipped within 5-7 working days.
Tumor necrosis factor receptor superfamily member 12A,FN14,CD266,TWEAKR,Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14)
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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