Human Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) CLIA Kit

Este producto es parte de TNFRSF12A - TNF receptor superfamily member 12A
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845€ (96 tests)

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935106861
info@markelab.com
name
Human Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx492063
tested applications
CLIA

Description

Human Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A/TWEAKR) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
CLIA Kits
Immunogen Target
Tumor Necrosis Factor Receptor Superfamily Member 12A (TNFRSF12A)
Reactivity
Human
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
125 pg/ml - 2000 pg/ml
Sensitivity
< 50 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
CLIA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-20 working days.
Storage
 Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
Tumor necrosis factor receptor superfamily member 12A,FN14,CD266,TWEAKR,Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14)
Background
CLIA Kits TNFRSF12A
Status
RUO
Note
The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

TNFRSF12A, also known as FN14 (Fibroblast Growth Factor Inducible 14), is a member of the tumor necrosis factor receptor superfamily (TNFRSF). This receptor is highly responsive to cellular stress signals, tissue damage, and inflammation, and it plays an essential role in tissue remodeling, inflammation, and wound healing. FN14 is particularly notable for its role as the primary receptor for TWEAK (TNF-like weak inducer of apoptosis), a member of the TNF superfamily of ligands. The binding of TWEAK to TNFRSF12A activates various downstream signaling pathways that influence processes including cell survival, proliferation, migration, and apoptosis. Its expression is typically low in most normal tissues but is upregulated under stress conditions such as injury, inflammation, or exposure to growth factors. Elevated levels of TNFRSF12A have been observed in a variety of pathological conditions, particularly in inflammatory diseases, cancer, cardiovascular disease, and fibrosis, where its activity is often associated with promoting cell survival, angiogenesis, and tissue remodeling.

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