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Human Tumor Necrosis Factor Receptor Superfamily Member 10D (TNFRSF10D) ELISA Kit
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935106861
info@markelab.com
Precio
537.5€ (96 tests)
Elisa Kits TNFRSF10D
proveedor
Abbexareference
abx521076Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Tumor Necrosis Factor Receptor Superfamily Member 10D (TNFRSF10D) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Tumor Necrosis Factor Receptor Superfamily Member 10D (TNFRSF10D) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TNFRSF10D, also known as TRAIL-R4 or DcR2 (Decoy Receptor 2), is a member of the tumor necrosis factor receptor superfamily, specifically binding TRAIL (TNF-related apoptosis-inducing ligand). Unlike apoptosis-inducing TRAIL receptors, such as TNFRSF10A (TRAIL-R1) and TNFRSF10B (TRAIL-R2), TNFRSF10D functions primarily as a “decoy” receptor. It plays a modulatory role by binding TRAIL and potentially preventing TRAIL-induced apoptosis in non-transformed cells. TNFRSF10D is unique among TRAIL receptors in that, while it possesses an intracellular tail with a truncated death domain, it lacks the full ability to transduce apoptotic signals. This feature gives it a protective function, especially in healthy cells where it modulates apoptosis sensitivity. TNFRSF10D is expressed in various normal tissues and has been implicated in protecting these tissues from unwanted TRAIL-mediated apoptosis. It is a subject of considerable interest in the field of cancer biology and immune modulation, as its expression pattern and function influence both tumor immunity and potential cancer cell resistance to TRAIL-based therapies.
Características del producto
category
ELISA Kits
immunogen target
Tumor Necrosis Factor Receptor Superfamily Member 10D (TNFRSF10D)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
Tumor necrosis factor receptor superfamily member 10D,DCR2,CD264,TRUNDD,TRAILR4,TRAIL-R4,Decoy receptor 2,TNF-related apoptosis-inducing ligand receptor 4,(TRAIL receptor 4
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
TNFRSF10D
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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