Human Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) Protein

Background

TNFRSF10C (TNF receptor superfamily member 10C), also known as TRAIL-R3 or Decoy Receptor 1 (DcR1), is part of the TNF receptor superfamily and specifically the death receptor subset involved in binding the ligand TRAIL (TNF-related apoptosis-inducing ligand). Unlike other TRAIL receptors, such as TNFRSF10A (TRAIL-R1) and TNFRSF10B (TRAIL-R2), which can initiate apoptosis upon TRAIL binding, TNFRSF10C is categorized as a “decoy” receptor. This classification is due to its structural attributes that prevent it from transmitting apoptotic signals. Instead, TNFRSF10C functions by binding TRAIL and preventing it from interacting with apoptosis-inducing receptors, thereby modulating apoptosis sensitivity in cells. TNFRSF10C is predominantly expressed in normal, non-transformed tissues, suggesting a role in protecting healthy cells from TRAIL-induced apoptosis. It has gained scientific interest due to its potential implications in cancer biology, where it may contribute to tumor resistance against TRAIL-based therapies.