Human Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) Protein
234€ (10 µg)
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Name
Human Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx166913
Tested Applications
WB, SDS-PAGE
Description
Human Tumor Necrosis Factor Receptor Superfamily, Member 10C Protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Glu32-Thr244 Tag: N-terminal His tag and GST tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 52.4 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | Tumor necrosis factor receptor superfamily member 10C,LIT,DCR1,TRID,CD263,TRAILR3,TRAIL-R3,DCR1-TNFR,Antagonist decoy receptor for TRAIL/Apo-2L,Decoy TRAIL receptor without death domain,TNF-related apoptosis-inducing ligand receptor 3 |
| Background | Protein TNFRSF10C |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
TNFRSF10C (TNF receptor superfamily member 10C), also known as TRAIL-R3 or Decoy Receptor 1 (DcR1), is part of the TNF receptor superfamily and specifically the death receptor subset involved in binding the ligand TRAIL (TNF-related apoptosis-inducing ligand). Unlike other TRAIL receptors, such as TNFRSF10A (TRAIL-R1) and TNFRSF10B (TRAIL-R2), which can initiate apoptosis upon TRAIL binding, TNFRSF10C is categorized as a “decoy” receptor. This classification is due to its structural attributes that prevent it from transmitting apoptotic signals. Instead, TNFRSF10C functions by binding TRAIL and preventing it from interacting with apoptosis-inducing receptors, thereby modulating apoptosis sensitivity in cells. TNFRSF10C is predominantly expressed in normal, non-transformed tissues, suggesting a role in protecting healthy cells from TRAIL-induced apoptosis. It has gained scientific interest due to its potential implications in cancer biology, where it may contribute to tumor resistance against TRAIL-based therapies.
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