Human Tumor Necrosis Factor Ligand Superfamily, Member 7 (TNFSF7) Protein
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935106861
info@markelab.com
Precio
2366€ (1 mg)
Protein CD70
proveedor
Abbexareference
abx069556Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 7 (TNFSF7) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
CD70, also known as TNFSF7 (Tumor Necrosis Factor Superfamily Member 7), is a transmembrane glycoprotein that belongs to the tumor necrosis factor (TNF) ligand superfamily. It is primarily expressed on the surface of activated immune cells, including T cells, B cells, dendritic cells (DCs), and natural killer (NK) cells. The expression of CD70 is tightly regulated and is typically transient, occurring upon immune cell activation, particularly during the adaptive immune response. CD70 plays a crucial role in immune cell interactions, contributing to T cell proliferation, differentiation, and the development of memory T cells. CD70 exerts its effects by binding to its receptor, CD27, which is a member of the TNF receptor superfamily. CD27 is constitutively expressed on naïve T cells, memory T cells, and NK cells, and its interaction with CD70 initiates intracellular signaling pathways that enhance immune activation and memory formation. This CD70-CD27 interaction is critical for effective immune responses, particularly during viral infections, tumor immunity, and in the context of autoimmune diseases.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Tumor Necrosis Factor Ligand Superfamily, Member 7 (TNFSF7)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
1 mg
size 2
5 mg
observerd MW
Molecular Weight: Calculated MW: 43.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln47-Val191 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
CD70
dry ice
No
availability
Shipped within 1-2 months.
alias
CD27L,LPFS3,CD27-L,CD27LG,TNFSF7,TNLG8A,CD70 antigen,CD27 ligand
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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