Human Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
556.25€ (96 tests)
Elisa Kits TNFSF11
proveedor
Abbexareference
abx253206Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TNFSF11, also known as RANKL (Receptor Activator of Nuclear Factor Kappa-Β Ligand), is a member of the tumor necrosis factor (TNF) superfamily. This protein is critical for bone metabolism, immune system regulation, and lymphoid tissue development. RANKL is primarily expressed on osteoblasts, T cells, and stromal cells, playing a major role in osteoclast differentiation and activation by binding to its receptor, RANK (Receptor Activator of Nuclear Factor Kappa-Β). Through the interaction between RANK and RANKL, this signaling pathway facilitates bone remodeling by controlling osteoclast-mediated bone resorption. RANKL is also vital in immune responses and is implicated in the formation of lymph nodes and mammary gland development. The physiological significance of TNFSF11 is underscored by its role in balancing bone formation and resorption. Disruptions in RANKL signaling can lead to metabolic bone disorders such as osteoporosis and osteopetrosis. RANKL is also an area of interest in cancer research, particularly in understanding bone metastasis in certain cancers, as well as autoimmune diseases where its role in immune regulation may contribute to chronic inflammation.
Características del producto
category
ELISA Kits
immunogen target
Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11)
reactivity
Human
test range
15.6 pg/ml - 1000 pg/ml
sensitivity
9.38 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
Tumor necrosis factor ligand superfamily member 11,ODF,OPGL,sOdf,CD254,OPTB2,RANKL,TNLG6B,TRANCE,hRANKL2,Osteoclast differentiation factor,Osteoprotegerin ligand,Receptor activator of nuclear factor kappa-B ligand,
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
TNFSF11
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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