Human Tumor Necrosis Factor (TNF) ELISA Kit
proveedor
Abbexareference
abx153320Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Tumor Necrosis Factor Alpha (TNFA) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Tumor Necrosis Factor Alpha (TNFA) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of TNF alpha (TNF alpha)No significant cross-reactivity or interference between TNF alpha (TNF alpha) and analogues was observed.
Background
Tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-α), is a multifaceted protein with characteristics of both an adipokine and a cytokine. It belongs to the TNF superfamily, a group of transmembrane proteins characterized by a homologous TNF domain. TNFα is produced and secreted by a variety of cells, including activated monocytes, macrophages, B cells, T cells, and fibroblasts. In its role as an adipokine, TNF contributes to insulin resistance and is linked to the development of type 2 diabetes in cases of obesity. As a cytokine, TNF plays a crucial role in cell signaling within the immune system. Has particular significance in sepsis. In animal models, the use of anti-TNFα treatments has been shown to reduce mortality during sepsis. Furthermore, in septic patients, the levels of TNFα in the bloodstream have been found to correlate with mortality rates. TNF is also known by several aliases, including TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, TNLG1F, and Tumor necrosis factor alpha.
Background
El factor de necrosis tumoral (TNF), también conocido como factor de necrosis tumoral alfa (TNF-α), es una proteína multifacética con características tanto de adipocina como de citoquina. Pertenece a la superfamilia del TNF, un grupo de proteínas transmembrana caracterizadas por un dominio TNF homólogo. El TNFα es producido y secretado por una variedad de células, incluidos monocitos activados, macrófagos, células B, células T y fibroblastos. En su papel de adipoquina, el TNF contribuye a la resistencia a la insulina y está relacionado con el desarrollo de diabetes tipo 2 en casos de obesidad. Como citoquina, el TNF desempeña un papel crucial en la señalización celular dentro del sistema inmunológico. Tiene especial importancia en la sepsis. En modelos animales, se ha demostrado que el uso de tratamientos anti-TNFα reduce la mortalidad durante la sepsis. Además, en pacientes sépticos, se ha descubierto que los niveles de TNFα en el torrente sanguíneo se correlacionan con las tasas de mortalidad. El TNF también se conoce con varios alias, incluidos TNF, DIF, TNF-alfa, TNFA, TNFSF2, factor de necrosis tumoral, TNF-α, TNLG1F y factor de necrosis tumoral alfa.
Características del producto
category
ELISA Kits
immunogen target
Tumor Necrosis Factor (TNF)
reactivity
Human
test range
1.56 pg/ml - 100 pg/ml
sensitivity
< 0.55 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
TNF
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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