Human Transmembrane Emp24-Domain Containing Protein 1 (TMED1) Protein (Active)
1235€ (100 µg)
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935106861
info@markelab.com
name
Human Transmembrane Emp24-Domain Containing Protein 1 (TMED1) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692409
tested applications
SDS-PAGE
Description
Human TMED1 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human TMED1 (Q13445) (Met1-Asn194) was expressed with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Transmembrane Emp24-Domain Containing Protein 1 (TMED1) |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 20.6 kDa Sequence Fragment: Met1-Asn194 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13445 |
| Gene ID | 11018 |
| OMIM | 605395 |
| Alias | TMED1,IL1RL1LG,IL1RL1L,Tp24; p24g1 |
| Background | Protein TMED1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TMED1, a member of the p24 protein family, is a type I transmembrane protein involved in vesicular trafficking, particularly in the early secretory pathway. TMED1 localizes to the endoplasmic reticulum (ER), ER-Golgi intermediate compartment (ERGIC), and the Golgi apparatus, where it regulates the transport and sorting of cargo proteins between cellular compartments. It interacts with coat protein complexes (COPI and COPII) to facilitate vesicle budding, cargo selection, and trafficking efficiency. TMED1 also plays a role in cellular signaling and homeostasis through its interaction with membrane-bound receptors and secretory proteins. It is widely expressed in various tissues, particularly in secretory cells and immune tissues, where it supports protein maturation, secretion, and immune regulation. Dysregulation of TMED1 has been linked to cancers and immune dysfunction, where altered trafficking pathways impair protein sorting and cellular communication. Knockdown studies show defects in vesicle formation, impaired protein transport, and disrupted Golgi integrity, emphasizing its role in maintaining secretory pathway dynamics, intracellular signaling, and cellular homeostasis.
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