Human Transforming Growth Factor Beta 1 (TGFb1) Protein
364€ (10 µg)
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Name
Human Transforming Growth Factor Beta 1 (TGFb1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx670199
Description
Human Transforming Growth Factor Beta 1 (TGFb1) Protein is a Recombinant protein expressed in CHO cells, consisting of two identical 112 amino acid polypeptide chains. TGF beta 1 is the most abundant isoform which is secreted by most cell types.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Transforming Growth Factor Beta 1 (TGFb1) |
| Host | CHO cells |
| Assay Type | Specific Activity: ≥ 2 × 107 U/mg. The ED50, as determined by the ability of TGF beta 1 to inhibit the IL-4 -dependent proliferation of Mouse HT-2 cells was determined to be less than or equal to 0.05 ng/ml. |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | 25.0 kDa |
| Purity | > 98% (SDS-PAGE/HPLC) |
| Size 1 | 10 µg |
| Form | Lyophilized |
| Availability | Shipped within 3-7 working days. |
| Storage | Store lyophilized at -20 °C. After reconstitution, aliquot and store at -20 °C for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01137 |
| Alias | CED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta |
| Background | Protein TGFB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in 100 µl sterile H2O. Further dilutions should be made with a buffer containing a carrier protein such as 0.1% BSA. Do not vortex. Endotoxin Level: < 0.1 ng/µg Centrifuge before opening to ensure complete recovery of vial contents. Concentration: Lyophilized form: Not applicable. After reconstitution: 0.1 mg/ml. |
Background
TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.
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