Human Transforming Growth Factor Beta 1 (TGFb1) Protein
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Description
Human Transforming Growth Factor Beta 1 (TGFb1) Protein is a Recombinant protein expressed in CHO cells. TGF beta 1 is the most abundant isoform which is secreted by most cell types.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Transforming Growth Factor Beta 1 (TGFb1) |
| Host | CHO cells |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 25.0 kDa Concentration: Lyophilized form: Not applicable. After reconstitution: 0.1 mg/ml. |
| Purity | > 98% (SDS-PAGE/HPLC) |
| Size 1 | 10 µg |
| Form | Lyophilized Reconstitute in 100 µl sterile H2O. Further dilutions should be made with a buffer containing a carrier protein such as 0.1% BSA. Do not vortex. |
| Buffer | Does not contain preservatives. |
| Availability | Shipped within 3-7 working days. |
| Storage | Store lyophilized at -20 °C. After reconstitution, aliquot and store at 20 °C for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01137 |
| Alias | CED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta |
| Background | Protein TGFB1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.
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TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease(CED) which known as progressive diaphyseal dysplasia 1(DPD1).
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TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease(CED) which known as progressive diaphyseal dysplasia 1(DPD1).
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