Human Transferrin (TF) Protein

Product specifications

Proteins and Peptides

Transferrin (TF)

Human

Optimal dilutions/concentrations should be determined by the end user.

Human

Unconjugated

100 mg

Lyophilized 

ELISA

Shipped within 3-7 working days.

Store at 4 °C for short-term storage. For long-term storage, store at -20 °C. Avoid repeated freeze/thaw cycles.

No

P02787

PRO1557,PRO2086,TFQTL1,HEL-S-71p

Protein TF

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Transferrin (TF) is a glycoprotein that plays a central role in iron homeostasis by binding and transporting iron ions in the blood to various tissues, including the liver, bone marrow, and brain. It interacts with transferrin receptors (TFR1 and TFR2) on cell surfaces to mediate iron uptake through receptor-mediated endocytosis, ensuring iron availability for critical cellular processes such as hemoglobin synthesis, DNA replication, and energy metabolism. TF is produced primarily in the liver and is widely distributed in blood plasma. Dysregulation of transferrin leads to iron-related disorders, such as anemia, iron overload (hemochromatosis), and neurodegenerative diseases like Alzheimer’s, where altered iron metabolism contributes to oxidative stress and neuronal damage. Elevated transferrin levels are also associated with liver disease and systemic inflammation. Knockout studies demonstrate impaired iron transport, reduced erythropoiesis, and disrupted metabolic processes, emphasizing its essential role in systemic iron regulation, cellular function, and red blood cell production.

Related Products

Human TF (Transferrin) ELISA Kit

Ver Producto

Human TF (Transferrin) High sensitive ELISA Kit

Ver Producto

TF antibody

Serotransferrin(TF) is a 77 kDa secreted protein which is also named as transferrin, siderophilin, beta-1 metal-binding globulin and belongs to a family of homologous iron-binding glycoproteins that encompasses lactoferrin(found both intracellular and in secretions, including milk), melanotrasferrin(present on melanoma cells) and ovotransferrin(present in egg white). TF is a multi-function protein with a primary role in transporting iron in a safe, redox-inactive state from absorption to utilization or storage sites around the body. The association of Tf with the immune system derives from its ability to restrict serum free-iron levels, creating low-iron environments where the infection capacity of pathogenic microorganisms is limited. TF is expressed predominantly in the liver and secreted in plasma, but lower amounts can be synthesized in other tissues such as the brain and the testis

Ver Producto