Human Serotransferrin (TF) Protein
468€ (100 mg)
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Name
Human Serotransferrin (TF) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx670229
Tested Applications
ELISA
Description
Human Serotransferrin (TF) Protein is a Native protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Serotransferrin (TF) |
| Host | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Conjugation | Unconjugated |
| Size 1 | 100 mg |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Availability | Shipped within 3-7 working days. |
| Storage | Store at 4°C for short-term storage. For long-term storage, store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P02787 |
| Alias | PRO1557,PRO2086,TFQTL1,HEL-S-71p |
| Background | Protein TF |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Transferrin (TF) is a glycoprotein that plays a central role in iron homeostasis by binding and transporting iron ions in the blood to various tissues, including the liver, bone marrow, and brain. It interacts with transferrin receptors (TFR1 and TFR2) on cell surfaces to mediate iron uptake through receptor-mediated endocytosis, ensuring iron availability for critical cellular processes such as hemoglobin synthesis, DNA replication, and energy metabolism. TF is produced primarily in the liver and is widely distributed in blood plasma. Dysregulation of transferrin leads to iron-related disorders, such as anemia, iron overload (hemochromatosis), and neurodegenerative diseases like Alzheimer’s, where altered iron metabolism contributes to oxidative stress and neuronal damage. Elevated transferrin levels are also associated with liver disease and systemic inflammation. Knockout studies demonstrate impaired iron transport, reduced erythropoiesis, and disrupted metabolic processes, emphasizing its essential role in systemic iron regulation, cellular function, and red blood cell production.
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