Human Transferrin Receptor Protein 1 / CD71 (TFRC) Protein

Este producto es parte de TFRC - Transferrin Receptor
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234€ (1 µg)

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935106861
info@markelab.com
name
Human Transferrin Receptor Protein 1 / CD71 (TFRC) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx680097
tested applications
SDS-PAGE

Description

Human Transferrin Receptor Protein 1 / CD71 (TFRC) Protein is a recombinant protein produced in Sf9, Baculovirus cells.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Transferrin Receptor Protein 1 / CD71 (TFRC)
Host
Insect
Origin
Human
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
1 µg
Size 2
5 µg
Size 3
50 µg
Form
Liquid 
Tested Applications
SDS-PAGE
Availability
Shipped within 5-10 working days.
Dry Ice
No
Alias
CD71,IMD46,T9,TFR,TFR1,TR,TRFR,p90
Background
Protein TFRC
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

TFRC, also known as CD71, is a transmembrane glycoprotein that mediates the uptake of transferrin-bound iron into cells via receptor-mediated endocytosis. It plays a crucial role in iron homeostasis, as iron is essential for processes like DNA synthesis, oxygen transport, and energy metabolism. TFRC expression is tightly regulated by cellular iron levels, proliferative demand, and hypoxia, with high expression observed in rapidly dividing cells, such as activated lymphocytes, erythroid progenitors, and cancer cells. Its overexpression is frequently observed in tumors, where increased iron uptake supports cancer cell proliferation and survival. TFRC is also involved in immune regulation and erythropoiesis, with its deficiency leading to anemia, impaired cell growth, and compromised immune responses. Targeting TFRC is being explored in cancer therapy as a mechanism for selective drug delivery and iron deprivation. Knockdown studies show impaired iron metabolism, reduced cell proliferation, and increased sensitivity to oxidative stress, emphasizing its central role in cellular growth, iron transport, and metabolic regulation.

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