Human Toll Like Receptor 4 (TLR4) Protein

Este producto es parte de TLR4 - toll like receptor 4
Human Toll Like Receptor 4 (TLR4) Protein

Pida mas información

935106861

info@markelab.com

Precio

208€ (10 µg)

Protein TLR4

proveedor

Abbexa

reference

abx168661

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human TLR4 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Background

Toll-like receptor 4 (TLR4) is a member of the toll-like receptor family of proteins, which play crucial roles in the innate immune system. TLR4 is well-known for its capacity to detect lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, which is a pathogen-associated molecular pattern (PAMP) that signals the presence of bacterial infections. Upon binding to LPS, TLR4 triggers a cascade of immune responses, including the activation of nuclear factor-kappa B (NF-κB) and the production of pro-inflammatory cytokines. These responses lead to a rapid immune reaction, making TLR4 essential for the early detection and management of bacterial infections. TLR4 is expressed in various cell types, including macrophages, dendritic cells, epithelial cells, and endothelial cells. The receptor is unique among TLRs due to its ability to signal through two distinct adaptor pathways: MyD88-dependent and TRIF-dependent pathways, which allows TLR4 to activate a broad array of immune responses. While critical in defense against infection, excessive or dysregulated TLR4 activation can contribute to chronic inflammation, autoimmune disorders, and septic shock, making TLR4 a target of interest for both enhancing and dampening immune responses therapeutically.

Características del producto

category

Proteins and Peptides

origin

Human

host

E. coli

immunogen target

Toll Like Receptor 4 (TLR4)

host

E. coli

conjugation

Unconjugated

form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

tested applications

WB, SDS-PAGE

size 1

10 µg

size 2

50 µg

size 3

100 µg

size 4

200 µg

size 5

500 µg

observerd MW

Molecular Weight: Calculated MW: 29.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Cys29-Leu253 Tag: N-terminal His tag

expression

Recombinant

purity

> 95%

buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

or code

TLR4

dry ice

No

availability

Shipped within 5-7 working days.

alias

Toll-like receptor 4,TOLL,CD284,TLR-4,ARMD10,hToll

uniprot id

https://www.uniprot.org/uniprotkb/O00206

note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

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