Human TNF Receptor Associated Factor 3 (TRAF3) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for TRAF3
proveedor
Abbexareference
abx153368Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human TNF Receptor Associated Factor 3 (TRAF3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human TRAF3 concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of TNF Receptor Associated Factor 3 (TRAF3)
Background
TRAF3 is an adaptor protein that regulates signaling downstream of receptors like CD40, BAFF-R, and Toll-like receptors (TLRs), playing a crucial role in immune regulation, lymphocyte activation, and antiviral responses. Unlike TRAF1 and TRAF2, TRAF3 functions as a negative regulator of the non-canonical NF-κB pathway by targeting NIK (NF-κB-inducing kinase) for degradation, thereby preventing constitutive activation of NF-κB2 signaling. TRAF3 is widely expressed in immune cells, where it regulates B-cell survival, interferon production, and immune tolerance. Dysregulation of TRAF3 is associated with B-cell malignancies, autoimmune diseases, and viral infections due to uncontrolled NF-κB activation and impaired immune signaling. Functional studies in knockout models demonstrate defects in B-cell homeostasis, increased susceptibility to autoimmunity, and reduced antiviral immunity, underscoring its dual role in restraining excessive signaling and supporting immune regulation.
Características del producto
category
ELISA Kits
immunogen target
TNF Receptor Associated Factor 3 (TRAF3)
reactivity
Human
test range
15.6 pg/ml - 1000 pg/ml
sensitivity
< 6.1 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
TRAF-3,TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, TNF receptor associated factor 3, RNF118
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TRAF3
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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