Human TNF receptor-associated factor 2 (TRAF2) ELISA Kit
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Description
Human TNF receptor-associated factor 2 (TRAF2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human TNF receptor-associated factor 2 (TRAF2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | TNF receptor-associated factor 2 (TRAF2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Sensitivity | < 0.38 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q12933 |
| Gene ID | 7186 |
| OMIM | 601895 |
| Alias | TRAF-2,TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117 |
| Background | Elisa kits for TRAF2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TRAF2 is a key adaptor protein that links TNF receptors and other immune receptors to downstream signaling pathways, particularly NF-κB and JNK activation, to regulate inflammation, cell survival, and apoptosis. TRAF2 interacts with TNFR1, TNFR2, and CD40 to recruit signaling intermediates like RIPK1 and IKK, facilitating the activation of NF-κB-dependent transcription of pro-survival and pro-inflammatory genes. It plays a critical role in immune homeostasis and inflammation, particularly in T cells, B cells, and macrophages. TRAF2 also regulates apoptosis by inhibiting caspase-8 activation through recruitment of cIAP proteins. Dysregulation of TRAF2 is implicated in autoimmune diseases, chronic inflammatory conditions, and cancers, where excessive or impaired NF-κB signaling contributes to disease pathogenesis. Knockout studies reveal embryonic lethality, defective TNF-induced NF-κB activation, and increased apoptosis, highlighting its essential role in maintaining cell survival and immune responses.
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anti- TRAF2 antibody
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
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anti- TRAF2 antibody
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
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