Human TNF receptor-associated factor 2 (TRAF2) ELISA Kit

Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for TRAF2
proveedor
Abbexareference
abx551109Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human TNF receptor-associated factor 2 (TRAF2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human TNF receptor-associated factor 2 (TRAF2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TRAF2 is a key adaptor protein that links TNF receptors and other immune receptors to downstream signaling pathways, particularly NF-κB and JNK activation, to regulate inflammation, cell survival, and apoptosis. TRAF2 interacts with TNFR1, TNFR2, and CD40 to recruit signaling intermediates like RIPK1 and IKK, facilitating the activation of NF-κB-dependent transcription of pro-survival and pro-inflammatory genes. It plays a critical role in immune homeostasis and inflammation, particularly in T cells, B cells, and macrophages. TRAF2 also regulates apoptosis by inhibiting caspase-8 activation through recruitment of cIAP proteins. Dysregulation of TRAF2 is implicated in autoimmune diseases, chronic inflammatory conditions, and cancers, where excessive or impaired NF-κB signaling contributes to disease pathogenesis. Knockout studies reveal embryonic lethality, defective TNF-induced NF-κB activation, and increased apoptosis, highlighting its essential role in maintaining cell survival and immune responses.
Características del producto
category
ELISA Kits
immunogen target
TNF receptor-associated factor 2 (TRAF2)
reactivity
Human
test range
0.78 ng/ml - 50 ng/ml
sensitivity
< 0.38 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
TRAF-2,TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TRAF2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Quizá le pueda interesar
anti- TRAF2 antibody

proveedor
FineTestreference
FNab10115Tested Applications
ELISA, WB, IF, IHCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalThe protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins ...
Precio a consultar
Ver másanti- TRAF2 antibody

proveedor
FineTestreference
FNab10272Tested Applications
ELISA, WB, IHCreactivity
human,mouse,ratstatus
RUOclonality
polyclonalThe protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins ...
Precio a consultar
Ver másRecombinant Human TRAF2

proveedor
FineTestreference
P0303Tested Applications
Western Blot, ELISAstatus
RUOPrecio a consultar
Ver más