Human TNF receptor-associated factor 1 (TRAF1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for TRAF1
proveedor
Abbexareference
abx383893Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human TNF receptor-associated factor 1 (TRAF1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human TRAF1 concentrations in serum, plasma and other biological fluids.
Background
TRAF1 is an adaptor protein in the tumor necrosis factor receptor (TNFR) superfamily signaling pathways, playing a role in regulating NF-κB and MAPK activation, apoptosis, and immune responses. TRAF1 interacts with TNFR1, TNFR2, and other members of the TNF receptor family to mediate downstream signaling, promoting survival and inflammatory responses. TRAF1 is predominantly expressed in immune cells, including T cells, B cells, and macrophages, where it modulates cytokine production and apoptosis inhibition. It forms heterodimers with TRAF2 to regulate receptor complex formation and downstream signal transduction. Dysregulation of TRAF1 contributes to autoimmune diseases, chronic inflammation, and certain cancers by altering TNF signaling and immune responses. Knockdown studies show defects in cytokine production, reduced NF-κB activation, and increased susceptibility to apoptosis, underscoring its role in balancing immune homeostasis and cell survival pathways.
Características del producto
category
ELISA Kits
immunogen target
TNF receptor-associated factor 1 (TRAF1)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.188 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma and other biological fluids.
size 1
96 tests
alias
TRAF-1,TRAF1,EBI6, MGC:10353, TNF receptor associated factor 1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TRAF1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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