Human Thyroid Hormone Receptor Beta (THRb) Protein
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Description
Human Thyroid Hormone Receptor Beta Protein is a recombinant Human protein expressed in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Thyroid Hormone Receptor Beta (THRb) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 28.6 kDa Observed MW (SDS-PAGE): 28 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Trp239-Glu457 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10828 |
| Alias | TRb,GRTH,PRTH,THR1,ERBA2,NR1A2,THRB1,THRB2,Trbeta,THRbeta,TRbeta1,C-ERBA-2,THRbeta1,Thrbeta2,C-ERBA-BETA,Nuclear receptor subfamily 1 group A member 2 |
| Background | Protein THRB |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Thyroid hormone receptor beta (THRB) is another member of the thyroid hormone receptor family, responsible for mediating the effects of thyroid hormones on gene expression Like THRA, THRB binds to thyroid hormones, primarily triiodothyronine (T3), and regulates the expression of genes involved in metabolism, development, and growth THRB is highly expressed in tissues such as the liver, kidney, and heart, where it plays a central role in regulating metabolic processes, including carbohydrate metabolism, lipid metabolism, and cholesterol homeostasis The receptor also influences the development of the central nervous system, particularly in processes like neuronal differentiation and maturation Mutations in THRB can cause a variety of thyroid-related disorders, including the thyroid hormone resistance syndrome, which leads to clinical features such as goiter, heart problems, and developmental delays in children In addition, THRB is implicated in cardiovascular health, where its dysfunction can contribute to arrhythmias, and in metabolic diseases, such as obesity and diabetes, due to its critical role in regulating energy metabolism and glucose homeostasis
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Thyroid Hormone Receptor Beta (THRB) Antibody
THRB Antibody is a Rabbit Polyclonal antibody against THRB. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008].
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Thyroid Hormone Receptor Beta (THRB) Antibody
THRB Antibody is a Rabbit Polyclonal antibody against THRB. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronineIt is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormoneKnockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormoneMutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH)Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
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