Human Thyroid Hormone Receptor Beta (THRb) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Thyroid Hormone Receptor Beta (THRb) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx168071
Tested Applications
WB, SDS-PAGE
Description
Human Thyroid Hormone Receptor Beta Protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Thyroid Hormone Receptor Beta (THRb) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Trp239-Glu457 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 28.6 kDa Observed MW (SDS-PAGE): 28 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10828 |
| Alias | TRb,GRTH,PRTH,THR1,ERBA2,NR1A2,THRB1,THRB2,Trbeta,THRbeta,TRbeta1,C-ERBA-2,THRbeta1,Thrbeta2,C-ERBA-BETA,Nuclear receptor subfamily 1 group A member 2 |
| Background | Protein THRB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Thyroid hormone receptor beta (THRB) is another member of the thyroid hormone receptor family, responsible for mediating the effects of thyroid hormones on gene expression Like THRA, THRB binds to thyroid hormones, primarily triiodothyronine (T3), and regulates the expression of genes involved in metabolism, development, and growth THRB is highly expressed in tissues such as the liver, kidney, and heart, where it plays a central role in regulating metabolic processes, including carbohydrate metabolism, lipid metabolism, and cholesterol homeostasis The receptor also influences the development of the central nervous system, particularly in processes like neuronal differentiation and maturation Mutations in THRB can cause a variety of thyroid-related disorders, including the thyroid hormone resistance syndrome, which leads to clinical features such as goiter, heart problems, and developmental delays in children In addition, THRB is implicated in cardiovascular health, where its dysfunction can contribute to arrhythmias, and in metabolic diseases, such as obesity and diabetes, due to its critical role in regulating energy metabolism and glucose homeostasis
Productos relacionados
Thyroid Hormone Receptor Beta (THRB) Antibody
THRB Antibody is a Rabbit Polyclonal antibody against THRB. The protein encoded by this gene is a nuclear hormone recept…
Ver producto
Thyroid Hormone Receptor Beta (THRB) Antibody
Thyroid Hormone Receptor beta Antibody is a Rabbit Polyclonal antibody against Thyroid Hormone Receptor β.…
Ver producto
Thyroid Hormone Receptor Beta (THRb) Antibody
Thyroid Hormone Receptor Beta Antibody is a Rabbit Polyclonal against Thyroid Hormone Receptor Beta.…
Ver producto