Human Testin (TES) Protein
273€ (10 µg)
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935106861
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name
Human Testin (TES) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690737
tested applications
SDS-PAGE
Description
Human Testin Protein is a recombinant protein from Human produced in E. coli. Recombinant Human Testin is produced by our E.coli expression system and the target gene encoding Met1-Ser421 is expressed with a 6His tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Testin (TES) |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 49.1 kDa Sequence Fragment: Met1-Ser421 Tag: C-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM PB, 150mM NaCl, 1mM DTT, pH 7.2. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | Q9UGI8 |
| Alias | TESS,TESS-2 |
| Background | Protein TES |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TES is a tumor suppressor protein that belongs to the LIM domain-containing family, functioning in actin cytoskeletal organization, cell adhesion, and signaling regulation. TES interacts with focal adhesion proteins and actin-binding molecules to regulate cellular processes such as cell spreading, migration, and morphology. It acts as a scaffolding protein at focal adhesions, mediating interactions between the actin cytoskeleton and signaling molecules to maintain cell adhesion and structural integrity. TES is also involved in transcriptional regulation by interacting with nuclear proteins, including transcription factors, to control gene expression associated with cell growth and differentiation. Downregulation of TES is commonly observed in cancers, where its loss disrupts cytoskeletal organization and promotes tumor progression, metastasis, and reduced cell adhesion. Knockdown studies reveal increased cell motility, reduced cell adhesion, and enhanced invasive capacity, emphasizing TES’s critical role in maintaining cytoskeletal stability, suppressing tumor growth, and regulating cellular architecture.
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