Human Telomeric Repeat Binding Factor 2 (TERF2) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein TERF2
proveedor
Abbexareference
abx167007Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Telomeric Repeat Binding Factor 2 Protein is a recombinant Human protein expressed in E. coli.
Background
TERF2, or TRF2, is a core component of the shelterin complex that binds double-stranded telomeric DNA to protect chromosome ends from degradation, DNA damage signaling, and end-to-end fusions. TERF2 functions by remodeling telomeric DNA into t-loop structures that mask chromosome termini and prevent activation of the ATM-mediated DNA damage response pathway. It also regulates telomere stability during replication and ensures proper telomere capping in both dividing and quiescent cells. TERF2 is essential for telomere maintenance, cellular longevity, and genomic stability, particularly in rapidly proliferating cells like stem cells and cancer cells. Dysregulation of TERF2 is implicated in diseases such as cancer, where its overexpression allows cells to bypass senescence, and in aging-related disorders, where telomere shortening accelerates cellular decline. Knockout studies show telomere deprotection, activation of DNA damage checkpoints, and increased chromosome end fusions, emphasizing TERF2's critical role in telomere capping, genomic stability, and cell fate regulation.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Telomeric Repeat Binding Factor 2 (TERF2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 36.3 kDa Observed MW (SDS-PAGE): 40 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg144-Gln438 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TERF2
dry ice
No
availability
Shipped within 5-7 working days.
alias
TERF2, TRBF2, TRF2,TTAGGG repeat-binding factor 2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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