Human Telomeric Repeat Binding Factor 2 (TERF2) Protein

Este producto es parte de TERF - Telomeric Repeat Binding Factor
Human Telomeric Repeat Binding Factor 2 (TERF2) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein TERF2

proveedor

Abbexa

reference

abx167007

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Telomeric Repeat Binding Factor 2 Protein is a recombinant Human protein expressed in E. coli.


Background

TERF2, or TRF2, is a core component of the shelterin complex that binds double-stranded telomeric DNA to protect chromosome ends from degradation, DNA damage signaling, and end-to-end fusions. TERF2 functions by remodeling telomeric DNA into t-loop structures that mask chromosome termini and prevent activation of the ATM-mediated DNA damage response pathway. It also regulates telomere stability during replication and ensures proper telomere capping in both dividing and quiescent cells. TERF2 is essential for telomere maintenance, cellular longevity, and genomic stability, particularly in rapidly proliferating cells like stem cells and cancer cells. Dysregulation of TERF2 is implicated in diseases such as cancer, where its overexpression allows cells to bypass senescence, and in aging-related disorders, where telomere shortening accelerates cellular decline. Knockout studies show telomere deprotection, activation of DNA damage checkpoints, and increased chromosome end fusions, emphasizing TERF2's critical role in telomere capping, genomic stability, and cell fate regulation.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Telomeric Repeat Binding Factor 2 (TERF2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 36.3 kDa Observed MW (SDS-PAGE): 40 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg144-Gln438 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TERF2


dry ice

No


availability

Shipped within 5-7 working days.


alias

TERF2, TRBF2, TRF2,TTAGGG repeat-binding factor 2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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