Human Telomeric Repeat Binding Factor 2 (TERF2) ELISA Kit
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935106861
info@markelab.com
Precio
611€ (96 tests)
Elisa kits for TERF2
proveedor
Abbexareference
abx571526Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Telomeric Repeat Binding Factor 2 (TERF2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Telomeric Repeat Binding Factor 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TERF2, or TRF2, is a core component of the shelterin complex that binds double-stranded telomeric DNA to protect chromosome ends from degradation, DNA damage signaling, and end-to-end fusions. TERF2 functions by remodeling telomeric DNA into t-loop structures that mask chromosome termini and prevent activation of the ATM-mediated DNA damage response pathway. It also regulates telomere stability during replication and ensures proper telomere capping in both dividing and quiescent cells. TERF2 is essential for telomere maintenance, cellular longevity, and genomic stability, particularly in rapidly proliferating cells like stem cells and cancer cells. Dysregulation of TERF2 is implicated in diseases such as cancer, where its overexpression allows cells to bypass senescence, and in aging-related disorders, where telomere shortening accelerates cellular decline. Knockout studies show telomere deprotection, activation of DNA damage checkpoints, and increased chromosome end fusions, emphasizing TERF2's critical role in telomere capping, genomic stability, and cell fate regulation.
Características del producto
category
ELISA Kits
immunogen target
Telomeric Repeat Binding Factor 2 (TERF2)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
0.1 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
TERF2, TRBF2, TRF2,TTAGGG repeat-binding factor 2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TERF2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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