Human Targeting Protein For Xklp2 (TPX2) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Microtubule-Associated Protein is a recombinant protein from Human produced in E. coli. Recombinant Human Microtubule-Associated Protein 1 Light Chain 3 alpha is produced by our E.coli expression system and the target gene encoding Met1-Phe121 is expressed with a 6His tag at the C-terminus.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Microtubule-Associated |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 15.3 kDa Sequence Fragment: Met1-Phe121 Tag: C-terminal 6 His tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM Tris, 20% Glycerol, 0.1M NaCl, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at < -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H492 |
| Background | Protein TPX2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Related Products
Human TPX2 (Targeting protein for Xklp2) ELISA Kit
Ver Producto
TPX2 antibody
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules(PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation(PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha(PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation(PubMed:26165940).
Ver Producto