Human Target of rapamycin complex subunit LST8 (MLST8) ELISA Kit
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Description
Human Target of rapamycin complex subunit LST8 (MLST8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human MLST8 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Target of rapamycin complex subunit LST8 (MLST8) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9BVC4 |
| Gene ID | 64223 |
| OMIM | 612190 |
| Alias | gable,GbetaL,GBL,GBLPop3,Lst8,TORC subunit LST8,Target of rapamycin complex subunit LST8 |
| Background | Elisa kits for MLST8 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
MTOR associated protein, LST8 homolog (MLST8), also known as mammalian lethal with SEC13 protein 8, is a core component of the mechanistic target of rapamycin (mTOR) complexes, mTORC1 and mTORC2. MLST8 is characterized by its seven WD40 repeats, forming a β-propeller structure that mediates interactions with other mTOR complex components. Within mTORC1, MLST8 contributes to substrate binding and mTOR kinase stability, enhancing its role in regulating cellular growth, metabolism, and response to nutrient availability. In mTORC2, MLST8 is crucial for the assembly and stabilization of the complex, which regulates cytoskeletal dynamics, cell survival, and metabolism. Dysregulation of MLST8 or its associated mTOR pathways has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. MLST8's functional importance makes it a potential therapeutic target for modulating mTOR activity in disease contexts.
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