Human T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) Protein
234€ (1 µg)
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Name
Human T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx680140
Tested Applications
SDS-PAGE
Description
Human T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) Protein is a recombinant protein produced in Sf9, Baculovirus cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) |
| Host | Insect |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 1 µg |
| Size 2 | 5 µg |
| Size 3 | 50 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | T-cell surface glycoprotein CD3 zeta chain,T3Z,CD3H,CD3Q,CD3Z,TCRZ,IMD25,CD3ZETA,CD3-ZETA,T-cell receptor T3 zeta chain |
| Background | Protein CD247 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD247 Molecule (CD247), also recognized as the T-cell receptor zeta chain (TCRζ), is an integral component of the T-cell receptor (TCR) complex, which plays a central role in T-cell activation and immune signaling. CD247 is primarily expressed on T lymphocytes, natural killer (NK) cells, and other immune cells and contributes to signal transduction during antigen recognition. It is characterized by its three immunoreceptor tyrosine-based activation motifs (ITAMs) within its intracellular domain, which become phosphorylated upon engagement of the TCR with peptide-MHC complexes. This phosphorylation event triggers downstream signaling cascades, ultimately leading to T-cell activation, proliferation, and cytokine production. CD247 is essential for the assembly, surface expression, and functional competence of the TCR-CD3 complex, and deficiencies or mutations in CD247 are associated with impaired immune responses, reduced TCR signaling, and susceptibility to infectious diseases or immune dysregulation. Aberrant CD247 expression has also been observed in various cancers, autoimmune disorders, and chronic infections, where it often correlates with T-cell exhaustion or dysfunction. Therapeutic approaches aimed at modulating CD247 function or restoring its expression hold promise for enhancing T-cell responses in immunotherapy, especially in cancer treatment and chronic viral infections. Furthermore, its role as a key molecule in immune checkpoint pathways has garnered attention for its potential as a target in the design of novel immune-boosting therapies.
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