Human T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) ELISA Kit
715€ (96 tests)
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935106861
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name
Human T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx386388
tested applications
ELISA
Description
Human T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P20963 |
| Alias | T-cell surface glycoprotein CD3 zeta chain,T3Z,CD3H,CD3Q,CD3Z,TCRZ,IMD25,CD3ZETA,CD3-ZETA,T-cell receptor T3 zeta chain |
| Background | Elisa kits for CD247 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
CD247 Molecule (CD247), also recognized as the T-cell receptor zeta chain (TCRζ), is an integral component of the T-cell receptor (TCR) complex, which plays a central role in T-cell activation and immune signaling. CD247 is primarily expressed on T lymphocytes, natural killer (NK) cells, and other immune cells and contributes to signal transduction during antigen recognition. It is characterized by its three immunoreceptor tyrosine-based activation motifs (ITAMs) within its intracellular domain, which become phosphorylated upon engagement of the TCR with peptide-MHC complexes. This phosphorylation event triggers downstream signaling cascades, ultimately leading to T-cell activation, proliferation, and cytokine production. CD247 is essential for the assembly, surface expression, and functional competence of the TCR-CD3 complex, and deficiencies or mutations in CD247 are associated with impaired immune responses, reduced TCR signaling, and susceptibility to infectious diseases or immune dysregulation. Aberrant CD247 expression has also been observed in various cancers, autoimmune disorders, and chronic infections, where it often correlates with T-cell exhaustion or dysfunction. Therapeutic approaches aimed at modulating CD247 function or restoring its expression hold promise for enhancing T-cell responses in immunotherapy, especially in cancer treatment and chronic viral infections. Furthermore, its role as a key molecule in immune checkpoint pathways has garnered attention for its potential as a target in the design of novel immune-boosting therapies.
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