Human T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Protein

767€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human T-Cell Surface Glycoprotein CD3 Epsilon Chain (CD3E) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691563
tested applications
SDS-PAGE
Description
Human CD3 epsilon Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the extracellular domain (Met 1-Asp 126) of human CD3E (NP_000724.1) precursor was fused with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Proteins and Peptides |
Immunogen Target | CD3 epsilon |
Host | HEK293 cells |
Origin | Human |
Observed MW | Molecular Weight: 13.2 kDa Sequence Fragment: Met1-Asp126 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
Expression | Recombinant |
Purity | > 80% (SDS-PAGE) |
Size 1 | 50 µg |
Size 2 | 500 µg |
Form | |
Tested Applications | SDS-PAGE |
Buffer | Lyophilized from sterile PBS, pH 7.4. |
Availability | Shipped within 5-15 working days. |
Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
NCBI Accession | NP_000724.1 |
Alias | T3E,TCRE,IMD18,CD3epsilon,T-cell surface glycoprotein CD3 epsilon chain,T-cell surface antigen T3/Leu-4 epsilon chain |
Background | Protein CD3E |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD3E (CD3 epsilon) is one of the key subunits of the T-cell receptor (TCR)-CD3 complex, which is vital for T-cell activation and immune responses. The TCR complex allows T lymphocytes to recognize and respond to antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). CD3E plays a critical role in assembling the TCR-CD3 complex and facilitating signal transduction after antigen recognition. The CD3E gene is located on chromosome 11q23 and encodes the CD3ε chain, a type I transmembrane protein essential for the assembly, expression, and signaling function of the TCR. Along with other CD3 subunits (CD3δ, CD3γ, and CD3ζ), CD3E forms part of the signal-transducing complex that transmits signals from the TCR upon antigen engagement. This signal initiates the cascade that leads to T-cell activation, differentiation, and proliferation, all of which are crucial for immune defense against pathogens.
Related Products

APC Anti-Mouse CD3E (145-2C11)
Ver Producto
Human CD3E (T-cell surface glycoprotein CD3 epsilon chain) ELISA Kit
Ver Producto