Human T-Cell Differentiation Antigen CD6 (CD6) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Human T-Cell Differentiation Antigen CD6 (CD6) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168113
tested applications
WB, SDS-PAGE
Description
Cluster Of Differentiation 6 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | T-Cell Differentiation Antigen CD6 (CD6) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 25.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly111-Glu313 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30203 |
| Alias | TP120,T-cell differentiation antigen CD6,T12 |
| Background | Protein CD6 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD6 is a type I transmembrane glycoprotein expressed on the surface of T cells, some B cells, and a subset of natural killer (NK) cells. It plays a critical role in the modulation of immune responses, particularly in T-cell activation, differentiation, and immune synapse formation. CD6 is involved in regulating the threshold of T-cell receptor (TCR) signaling and acts as a co-stimulatory receptor that modulates immune responses. CD6 is expressed in the thymus, where it is involved in T-cell development, including positive and negative selection during thymic maturation. In peripheral tissues, CD6 helps facilitate immune responses against pathogens, while maintaining immune tolerance to self-antigens. Dysregulation of CD6 signaling is implicated in a range of immune-related conditions, including autoimmune diseases, inflammatory disorders, and certain types of cancer.
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