Human T-Cell Activation Antigen, Increased Late Expression (TACTILE) CLIA Kit
845€ (96 tests)
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935106861
info@markelab.com
name
Human T-Cell Activation Antigen, Increased Late Expression (TACTILE) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx496420
tested applications
CLIA
Description
Human T-Cell Activation Antigen, Increased Late Expression (TACTILE) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | T-Cell Activation Antigen, Increased Late Expression (TACTILE) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 78 pg/ml - 5000 pg/ml |
| Sensitivity | < 29 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | T-cell surface protein tactile,TACTILE,T cell-activated increased late expression protein |
| Background | CLIA Kits CD96 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
The CD96 molecule, also known as TACTILE (T-cell-activated increased late expression), is a transmembrane glycoprotein predominantly expressed on the surface of NK cells and certain subsets of T cells. This protein plays a crucial role in the regulation of immune responses, specifically within the innate immune system, by modulating the activity of NK cells. CD96 is part of the immunoglobulin superfamily and is closely related to other checkpoint receptors such as TIGIT (T cell immunoreceptor with Ig and ITIM domains) and CD226. It has structural and functional similarities with these receptors, which are involved in immune cell interactions and responses to cellular stress signals, infection, and malignant transformations. CD96 binds to the ligand CD155, also known as poliovirus receptor (PVR), which is broadly expressed on various cell types, including endothelial cells and tumor cells. Through its interaction with CD155, CD96 modulates NK cell cytotoxicity and plays a part in controlling the inflammatory response and immunological synapse formation between NK cells and target cells. By balancing activating and inhibitory signals, CD96 ensures immune homeostasis, minimizing the risk of autoimmune responses while enabling effective pathogen and tumor surveillance.
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