Human Switch-associated protein 70 (SWAP70) ELISA Kit
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935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits SWAP70
proveedor
Abbexareference
abx251622Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Switch-associated protein 70 (SWAP70) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Switch-associated protein 70 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SWAP70 is a nuclear and cytoplasmic adaptor protein involved in actin cytoskeleton remodeling, signal transduction, and B-cell activation. It functions as a guanine nucleotide exchange factor (GEF) for Rac1, facilitating actin polymerization and cell shape changes during processes such as immune cell migration, phagocytosis, and endocytosis. SWAP70 plays a critical role in B-cell development, class switch recombination (CSR), and antigen receptor signaling, linking extracellular signals to cytoskeletal rearrangement and nuclear responses. It is expressed in hematopoietic cells, epithelial tissues, and immune cells, where it coordinates cell migration, adhesion, and immune responses. Dysregulation of SWAP70 is associated with autoimmune diseases, cancer metastasis, and inflammatory disorders due to impaired actin regulation and signaling balance. Knockout studies reveal defects in B-cell maturation, impaired immune cell migration, and reduced immune responses, highlighting its essential role in cytoskeletal remodeling, cell signaling, and adaptive immunity.
Características del producto
category
ELISA Kits
immunogen target
Switch-associated protein 70 (SWAP70)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.09 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
SWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70, switching B-cell complex subunit switching B cell complex subunit SWAP70
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
SWAP70
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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