Human Suppressors Of Cytokine Signaling 2 (SOCS2) Protein

Este producto es parte de SOCS - Suppressor of cytokine signaling
Human Suppressors Of Cytokine Signaling 2 (SOCS2) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein SOCS2

proveedor

Abbexa

reference

abx166696

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Suppressors Of Cytokine Signaling 2 Protein is a recombinant Human protein expressed in E. coli.


Background

SOCS2 is a member of the SOCS family of negative regulators that controls cytokine signaling through the JAK/STAT pathway by binding to phosphorylated cytokine receptors and targeting them for proteasomal degradation. SOCS2 primarily regulates growth hormone (GH), insulin-like growth factor 1 (IGF-1), and IL-6 signaling, modulating processes such as cell growth, differentiation, and metabolism. It is expressed in a variety of tissues, including the liver, skeletal muscle, and immune cells, where it balances cytokine-mediated cellular responses and prevents excessive signaling. SOCS2 plays a role in regulating growth and metabolism, as its deletion results in gigantism and increased sensitivity to growth hormone signaling. Dysregulation of SOCS2 has been linked to inflammatory diseases, insulin resistance, and cancer, where altered cytokine regulation promotes abnormal cell growth and survival. Knockout studies reveal excessive growth, immune cell hyperactivation, and increased susceptibility to inflammatory disorders, highlighting its role in maintaining cytokine signaling and growth homeostasis.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Suppressors Of Cytokine Signaling 2 (SOCS2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 26.0 kDa Observed MW (SDS-PAGE): 26 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Val198 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

SOCS2


dry ice

No


availability

Shipped within 5-7 working days.


alias

CIS2,SSI2,Cish2,SSI-2,SOCS-2,STATI2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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reactivity

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