Human Suppressors Of Cytokine Signaling 1 (SOCS1) CLIA Kit
845€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Suppressors Of Cytokine Signaling 1 (SOCS1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx495392
tested applications
CLIA
Description
Human Suppressors Of Cytokine Signaling 1 (SOCS1) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Suppressors Of Cytokine Signaling 1 (SOCS1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.114 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | AISIMD,CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP-3,TIP3 |
| Background | CLIA Kits SOCS1 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SOCS1 is a critical negative regulator of cytokine signaling pathways, particularly those mediated by the Janus kinase/signal transducer and activator of transcription (JAK/STAT) system. It functions by directly binding to JAKs through its SH2 domain and targeting them for proteasomal degradation via its SOCS box, which recruits components of the ubiquitin-proteasome machinery. SOCS1 regulates immune responses by preventing excessive cytokine signaling, particularly in interferon-γ, IL-6, and IL-4 pathways, ensuring proper immune homeostasis and inflammation control. It is highly expressed in immune cells, including T cells, macrophages, and dendritic cells, where it regulates processes like cytokine sensitivity, inflammation, and T-cell activation. Dysregulation of SOCS1 contributes to autoimmune diseases, chronic inflammation, and cancer due to hyperactivation of cytokine signaling. Knockout studies reveal severe inflammatory responses, lymphocyte activation, and neonatal lethality, underscoring its essential role in immune regulation and cytokine signaling balance.
Related Products
Human SOCS1(Suppressor of cytokine signaling 1) ELISA Kit
Ver Producto
Mouse SOCS1(Suppressor of cytokine signaling 1) ELISA Kit
Ver Producto