Human 14-3-3 Protein Sigma (SFN) ELISA Kit

Este producto es parte de SFN - stratifin
Human 14-3-3 Protein Sigma (SFN) ELISA Kit
715€ (96 tests)

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Name
Human 14-3-3 Protein Sigma (SFN) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx153184
Tested Applications
ELISA

Description

Human 14-3-3 Protein Sigma (SFN) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human 14-3-3 Protein Sigma (SFN) concentrations in serum, plasma, cerebrospinal fluid and other biological fluids. This assay has high sensitivity and excellent specificity for detection of 14-3-3 Protein Sigma (SFN)

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
14-3-3 Protein Sigma (SFN)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
31.25 pg/ml - 2000 pg/ml
Sensitivity
< 11.9 pg/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma, cerebrospinal fluid and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
SFN, YWHAS, Stratifin,14-3-3σ protein
Background
Elisa Kits for: SFN
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Stratifin (SFN) , also known as 14-3-3 sigma, is a member of the 14-3-3 protein family that acts as a critical regulator of cell cycle progression, DNA damage response, and cellular stress. It binds to phosphorylated serine/threonine residues on target proteins, facilitating their localization, stability, and activity. Stratifin is specifically involved in G2/M cell cycle checkpoint control by sequestering cyclin-dependent kinase complexes like CDC25C in the cytoplasm, preventing premature mitotic entry under DNA damage conditions. It is highly expressed in epithelial tissues and is essential for maintaining epithelial cell integrity, polarity, and stress responses. Stratifin acts as a tumor suppressor by inhibiting uncontrolled proliferation; its downregulation has been observed in breast, lung, and gastrointestinal cancers due to epigenetic silencing. Functional studies reveal its role in mediating stress-induced growth arrest and apoptosis, underscoring its importance in tumor suppression, DNA repair, and cell cycle regulation.

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