Human 14-3-3 Protein Sigma (SFN) Protein
234€ (5 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human 14-3-3 Protein Sigma (SFN) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073141
Tested Applications
SDS-PAGE
Description
Human 14-3-3 Protein Sigma (SFN) Protein is a recombinant protein kinase.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | 14-3-3 Protein Sigma (SFN) |
| Host | E. coli |
| Assay Type | Activity: Not tested |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 25 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P31947 |
| Alias | SFN, YWHAS, Stratifin,14-3-3σ protein |
| Background | Protein SFN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Stratifin (SFN) , also known as 14-3-3 sigma, is a member of the 14-3-3 protein family that acts as a critical regulator of cell cycle progression, DNA damage response, and cellular stress. It binds to phosphorylated serine/threonine residues on target proteins, facilitating their localization, stability, and activity. Stratifin is specifically involved in G2/M cell cycle checkpoint control by sequestering cyclin-dependent kinase complexes like CDC25C in the cytoplasm, preventing premature mitotic entry under DNA damage conditions. It is highly expressed in epithelial tissues and is essential for maintaining epithelial cell integrity, polarity, and stress responses. Stratifin acts as a tumor suppressor by inhibiting uncontrolled proliferation; its downregulation has been observed in breast, lung, and gastrointestinal cancers due to epigenetic silencing. Functional studies reveal its role in mediating stress-induced growth arrest and apoptosis, underscoring its importance in tumor suppression, DNA repair, and cell cycle regulation.
Productos relacionados
14-3-3 Protein Sigma (SFN) Antibody
SFN Antibody is a Rabbit Polyclonal antibody against SFN. 14-3-3 proteins regulate many cellular processes relevant to c…
Ver producto
14-3-3 Protein Sigma (SFN) Antibody
This product is currently in development. The lead time for this product may be several months. Please contact us at…
Ver producto
14-3-3 Protein Sigma (SFN) Antibody
SFN Antibody is a Rabbit Polyclonal antibody against SFN.…
Ver producto