Human Sphingosine 1 Phosphate Receptor 1 (S1PR1) CLIA Kit
845€ (96 tests)
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935106861
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name
Human Sphingosine 1 Phosphate Receptor 1 (S1PR1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx493990
tested applications
CLIA
Description
Human Sphingosine 1 Phosphate Receptor 1 (S1PR1) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Sphingosine 1 Phosphate Receptor 1 (S1PR1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.058 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | S1PR1,CD363,CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,S1P1,endothelial differentiation G protein-coupled receptor 1 |
| Background | CLIA Kits S1PR1 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
S1PR1 is a G protein-coupled receptor that binds sphingosine-1-phosphate (S1P), a bioactive lipid involved in immune regulation, vascular development, and cellular migration. S1PR1 is widely expressed in endothelial cells, lymphocytes, and smooth muscle cells, where it regulates vascular barrier integrity, immune cell trafficking, and angiogenesis. Activation of S1PR1 by S1P triggers signaling pathways involving Gi proteins, leading to activation of PI3K/Akt, MAPK, and Rac, which regulate cell survival, proliferation, and cytoskeletal dynamics. In the immune system, S1PR1 is critical for lymphocyte egress from lymphoid tissues into circulation, making it a key target for immunosuppressive therapies, such as fingolimod, used in treating multiple sclerosis. In the vasculature, S1PR1 maintains endothelial barrier function and regulates vascular permeability. Dysregulation of S1PR1 signaling is associated with inflammatory diseases, cardiovascular disorders, and cancer, where it promotes tumor angiogenesis and immune evasion. Therapeutically, S1PR1 modulators are being developed for autoimmune diseases, inflammatory conditions, and cancer, highlighting its critical role in immune and vascular homeostasis.
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