Human SLAM Family Member 5 (CD84) Protein

Background

CD84 is a surface glycoprotein that belongs to the Signaling Lymphocytic Activation Molecule (SLAM) family of receptors, which are part of the larger immunoglobulin superfamily (IgSF). It plays a significant role in the regulation of immune cell interactions, particularly in B and T lymphocytes, natural killer (NK) cells, and myeloid cells. CD84 is predominantly expressed in hematopoietic cells, where it mediates cell signaling processes related to immune regulation, cell adhesion, and inflammatory responses. CD84 is encoded by the CD84 gene, which is located on chromosome 1q23. It is widely expressed on immune cells such as B cells, T cells, dendritic cells, and monocytes, with notable expression also found on platelets. This molecule is critical for maintaining the balance of immune responses, including both activation and inhibition of immune functions. Due to its regulatory functions, CD84 has attracted considerable attention in immunology, cancer research, and autoimmune disease studies.