Human SLAM Family Member 5 (CD84) Protein

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Descripción

CD84 is a surface glycoprotein that belongs to the Signaling Lymphocytic Activation Molecule (SLAM) family of receptors, which are part of the larger immunoglobulin superfamily (IgSF). It plays a significant role in the regulation of immune cell interactions, particularly in B and T lymphocytes, natural killer (NK) cells, and myeloid cells. CD84 is predominantly expressed in hematopoietic cells, where it mediates cell signaling processes related to immune regulation, cell adhesion, and inflammatory responses. CD84 is encoded by the CD84 gene, which is located on chromosome 1q23. It is widely expressed on immune cells such as B cells, T cells, dendritic cells, and monocytes, with notable expression also found on platelets. This molecule is critical for maintaining the balance of immune responses, including both activation and inhibition of immune functions. Due to its regulatory functions, CD84 has attracted considerable attention in immunology, cancer research, and autoimmune disease studies.

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anti- CD84 antibody

Self-ligand receptor of the signaling lymphocytic activation molecule(SLAM) family. SLAM receptors triggered by homo-or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer(NK) cell cytotoxicity dependent on SH2D1A and SH2D1B(By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells(PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity(By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1(PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2(By similarity).

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SLAM Family Member 5 (CD84) Antibody

CD84 Antibody is a Rabbit Polyclonal antibody against CD84. This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants.

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SLAM Family Member 5 (CD84) Antibody

Members of the CD2 (see MIM 186990) subgroup of the Ig superfamily, such as CD84, have similar patterns of conserved disulfide bonds and function in adhesion interactions between T lymphocytes and accessory cells.

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