Human Signal Regulatory Protein Gamma (SIRPg) Protein

Background

Signal Regulatory Protein Gamma (SIRPG) is a member of the signal regulatory protein (SIRP) family, a subset of the immunoglobulin superfamily of cell-surface receptors. SIRPG is encoded by the SIRPG gene located on chromosome 20p13 in humans and is closely related to other family members such as SIRPA (SIRP alpha) and SIRPB (SIRP beta). This receptor plays an important role in immune cell signaling, particularly in immune regulation and cell-cell communication. SIRPG is primarily expressed on cells of the immune system, including T cells and dendritic cells, and plays a significant role in regulating cellular responses involved in immunity. Unlike SIRPA, which interacts with the CD47 ligand on other cells to inhibit macrophage phagocytosis and dendritic cell responses, SIRPG’s role centers on modulating T cell interactions, particularly in the context of immune responses and tissue homeostasis.