Human Signal Regulatory Protein Alpha (SIRPa) ELISA Kit
546€ (96 tests)
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935106861
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name
Human Signal Regulatory Protein Alpha (SIRPa) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx253176
tested applications
ELISA
Description
Human Signal Regulatory Protein Alpha (SIRPa) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SIRPA concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Signal Regulatory Protein Alpha (SIRPa) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | 0.1 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P78324 |
| OMIM | 602461 |
| Alias | Tyrosine-protein phosphatase non-receptor type substrate 1,BIT,MFR,P84,SIRP,MYD-1,SHPS1,CD172A,PTPNS1,SHP substrate 1,SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen |
| Background | Elisa kits for SIRPA |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Signal regulatory protein alpha (SIRPA) is a transmembrane glycoprotein encoded by the SIRPA gene in humans, primarily expressed on myeloid cells such as macrophages, dendritic cells, and neutrophils, and to a lesser extent on neurons. SIRPA belongs to the immunoglobulin superfamily (IgSF) and functions as an inhibitory receptor, playing a critical role in immune homeostasis, cellular signaling, and cell-cell interactions. SIRPA interacts primarily with CD47, a widely expressed protein known as the “don’t eat me” signal on host cells. This interaction is fundamental for immune surveillance, as it prevents macrophages and other immune cells from targeting healthy self-cells for phagocytosis, thereby maintaining tolerance to self while supporting immune responses against foreign antigens and damaged cells. SIRPA is integral in modulating immune responses and is implicated in a range of physiological processes, including cell migration, cell adhesion, and tissue homeostasis. Research indicates that SIRPA is not only crucial in the innate immune system but also impacts adaptive immunity. Dysregulation or mutations of SIRPA have been linked to autoimmunity, cancer, and other pathologies due to its role in immune evasion, particularly in the context of cancer, where many tumor cells upregulate CD47 to escape immune clearance.
