Human Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Protein

Este producto es parte de SIGLEC - sialic acid binding Ig like lectin
Human Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Protein
208€ (10 µg)

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Name
Human Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx069068
Tested Applications
WB, SDS-PAGE

Description

Human Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5) is a recombinant Human protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Sialic Acid Binding Ig Like Lectin 5 (SIGLEC5)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Phe458-Lys551
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 17.2 kDa  Observed MW (SDS-PAGE): 20 kDa
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
O15389
Alias
CD170,OBBP2,CD33L2,OB-BP2,SIGLEC-5,Obesity-binding protein 2,CD33 antigen-like 2
Background
Protein SIGLEC5
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

SIGLEC5 is an inhibitory receptor expressed on monocytes, neutrophils, and B cells. It binds to sialic acid-containing glycans on host and microbial surfaces, modulating immune responses to avoid excessive inflammation. Through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs), SIGLEC5 dampens activation signals and helps maintain immune tolerance. This protein also plays a role in preventing inappropriate immune responses during pregnancy and infection. Genetic fusion events between SIGLEC5 and SIGLEC14 have been noted, affecting the functional balance between activation and inhibition. SIGLEC5 is studied for its involvement in autoimmune diseases and infections.

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