Human Sialic Acid Binding Ig Like Lectin 2 / SIGLEC2 (CD22) ELISA Kit
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935106861
info@markelab.com
Precio
525€ (96 tests)
Elisa Kits CD22
proveedor
Abbexareference
abx253173Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Sialic Acid Binding Ig Like Lectin 2 / SIGLEC2 (CD22) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sialic Acid Binding Ig Like Lectin 2 / SIGLEC2 (CD22) concentrations in serum, plasma and other biological fluids.
Background
CD22, also known as Siglec-2, is a member of the sialic acid-binding immunoglobulin-like lectins (Siglec) family and is predominantly expressed on B cells. It plays a crucial role in modulating B-cell receptor (BCR) signaling and maintaining B-cell tolerance, making it an essential molecule in the regulation of the immune system. CD22 is primarily found on mature B cells, acting both as an inhibitory coreceptor to dampen BCR signaling and as an adhesion molecule involved in cell-cell interactions. CD22 is essential for maintaining the delicate balance between immune activation and tolerance, preventing excessive immune responses that could lead to autoimmune diseases. It is an inhibitory receptor that modulates B-cell activity by recruiting SHP-1, a phosphatase that negatively regulates B-cell signaling pathways. In this capacity, CD22 fine-tunes the immune response to antigens, ensuring that B cells are appropriately activated and preventing autoimmunity.
Características del producto
category
ELISA Kits
immunogen target
Sialic Acid Binding Ig Like Lectin 2 / SIGLEC2 (CD22)
reactivity
Human
test range
15.6 pg/ml - 1000 pg/ml
sensitivity
9.38 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Other biological fluids
size 1
96 tests
alias
SIGLEC2,SIGLEC-2,B-cell receptor CD22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,T-cell surface antigen Leu-14
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
CD22
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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