Human Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) ELISA Kit

Este producto es parte de SIGLEC - sialic acid binding Ig like lectin
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715€ (96 tests)

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935106861
info@markelab.com
name
Human Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx545883
tested applications
ELISA

Description

Human Sialic acid-binding Ig-like lectin 15 (SIGLEC15) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sialic acid-binding Ig-like lectin 15 (SIGLEC15) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
ELISA Kits
Immunogen Target
Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.06 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q6ZMC9
OMIM
618105
Alias
CD33L3,HsT1361,SIGLEC-15,CD33 antigen-like 3
Background
Elisa kits for SIGLEC15
Status
RUO
Note
Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

SIGLEC15 is predominantly expressed on macrophages, dendritic cells, and osteoclasts. Unlike other Siglecs, SIGLEC15 shows specificity for modified sialic acids and is crucial for osteoclast development and bone resorption. It interacts with ligands on T cells to regulate immune responses, making it a potential target for cancer immunotherapy as it suppresses anti-tumor immunity. SIGLEC15 is highly expressed in the tumor microenvironment and has been associated with poor prognosis in certain cancers. Its roles extend to tissue remodeling and maintaining immune homeostasis in non-inflammatory conditions.

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