Human Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) ELISA Kit

715€ (96 tests)
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935106861
info@markelab.com
name
Human Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx545883
tested applications
ELISA
Description
Human Sialic acid-binding Ig-like lectin 15 (SIGLEC15) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Sialic acid-binding Ig-like lectin 15 (SIGLEC15) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
Category | ELISA Kits |
Immunogen Target | Sialic Acid Binding Ig Like Lectin 15 (SIGLEC15) |
Reactivity | Human |
Detection Method | Colorimetric |
Assay Data | Quantitative |
Assay Type | Sandwich |
Test Range | 0.156 ng/ml - 10 ng/ml |
Sensitivity | < 0.06 ng/ml |
Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
Size 1 | 96 tests |
Size 2 | 5 × 96 tests |
Size 3 | 10 × 96 tests |
Form | Lyophilized |
Tested Applications | ELISA |
Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
Availability | Shipped within 5-15 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
Dry Ice | No |
UniProt ID | Q6ZMC9 |
OMIM | 618105 |
Alias | CD33L3,HsT1361,SIGLEC-15,CD33 antigen-like 3 |
Background | Elisa kits for SIGLEC15 |
Status | RUO |
Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SIGLEC15 is predominantly expressed on macrophages, dendritic cells, and osteoclasts. Unlike other Siglecs, SIGLEC15 shows specificity for modified sialic acids and is crucial for osteoclast development and bone resorption. It interacts with ligands on T cells to regulate immune responses, making it a potential target for cancer immunotherapy as it suppresses anti-tumor immunity. SIGLEC15 is highly expressed in the tumor microenvironment and has been associated with poor prognosis in certain cancers. Its roles extend to tissue remodeling and maintaining immune homeostasis in non-inflammatory conditions.
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