Human SH2 Domain Containing 4A (SH2D4A) ELISA Kit

Este producto es parte de SH2D - SH2 domain containing
Human SH2 Domain Containing 4A (SH2D4A) ELISA Kit

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935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for SH2D4A

proveedor

Abbexa

reference

abx383171

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human SH2 Domain Containing 4A (SH2D4A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SH2D4A concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

SH2D4A is an SH2 domain-containing protein that functions as a negative regulator of signaling pathways activated by receptor tyrosine kinases and cytokine receptors. It interacts with signaling molecules like STAT proteins and phosphatases to inhibit downstream pathways such as JAK/STAT and MAPK, modulating processes like cell proliferation, differentiation, and immune responses. SH2D4A is predominantly expressed in immune cells and tissues involved in hematopoiesis, where it plays a role in regulating cytokine signaling and immune homeostasis. It functions as a tumor suppressor in certain contexts, inhibiting excessive proliferation and survival signaling. Dysregulation or loss of SH2D4A has been linked to cancer progression and immune disorders due to uncontrolled activation of cytokine signaling. Knockout studies reveal hyperactive immune responses, abnormal proliferation, and defects in cytokine regulation, emphasizing its role as a critical negative regulator of cellular signaling pathways.

Características del producto

category

ELISA Kits


immunogen target

SH2 Domain Containing 4A (SH2D4A)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.094 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

PPP1R38, SH2A


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

SH2D4A


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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