Human Serine/Threonine-Protein Kinase LMTK1 (AATK) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Human Serine/Threonine-Protein Kinase LMTK1 (AATK) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168088
tested applications
WB, SDS-PAGE
Description
Apoptosis Associated Tyrosine Kinase Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Serine/Threonine-Protein Kinase LMTK1 (AATK) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 20.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu1216-Ala1374 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6ZMQ8 |
| Alias | AATYK,AATYK1,LMR1,LMTK1,PPP1R77,P35bp,AATK |
| Background | Protein AATK |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AATK (Apoptosis-Associated Tyrosine Kinase), also known as LMTK1 (Lemur Tyrosine Kinase 1), is a member of the serine/threonine-protein kinase family. PTKs (Protein Tyrosine Kinases) facilitate the transfer of the gamma-phosphoryl group from ATP to tyrosine (Tyr) residues. LMTK1, also known as Apoptosis-associated tyrosine kinase (AATK) or AATYK, is a cytoplasmic kinase with an extensive C-terminal region. The expression of LMTK1 is elevated during growth arrest and apoptosis in myeloid cells . LMTK1 is implicated in neural differentiation and serves as a regulator for the Na-K-2Cl cotransporter, a membrane protein involved in cell proliferation, survival, epithelial transport, and blood pressure control. The protein comprises a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. Studies on the mouse homologue suggest its potential role in inducing growth arrest and apoptosis in myeloid precursor cells. Additionally, it may play a part in promoting differentiation in neuronal cells . Recent reports also highlight its suppressive effect on melanoma development
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