Human Semaphorin 4D (SEMA4D) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Semaphorin 4D (SEMA4D) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168082
tested applications
WB, SDS-PAGE
Description
Human Semaphorin 4D Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Semaphorin 4D (SEMA4D) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 16.2 kDa Observed MW (SDS-PAGE): 18 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe502-Phe636 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92854 |
| Gene ID | 10507 |
| OMIM | 601866 |
| Alias | Semaphorin-4D,A8,GR3,BB18,CD100,COLL4,SEMAJ,coll-4,C9orf164,M-sema-G |
| Background | Protein SEMA4D |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SEMA4D, also known as CD100, is a member of the semaphorin family, a group of proteins primarily involved in axonal guidance during neural development. SEMA4D was initially identified for its role in the nervous system, where it facilitates signaling for axonal growth and directionality. It is now known to have significant functions beyond neural tissue, impacting immune system responses, vascular biology, and cancer. By interacting with various receptor families, SEMA4D modulates cell-cell communication, cell migration, angiogenesis, and immune activation. In the immune system, SEMA4D is found on T cells, B cells, and dendritic cells, where it regulates immune responses by influencing cell adhesion, migration, and cytokine production. It has also become a molecule of interest in oncology, given its role in tumor progression, angiogenesis, and metastasis. SEMA4D is overexpressed in several cancer types, and its inhibition has shown promising results in reducing tumor growth and spread. Additionally, SEMA4D's involvement in blood vessel growth (angiogenesis) through its effects on endothelial cells and pericytes further highlights its importance in cancer biology and therapeutic potential.
Related Products
Recombinant Human SEMA4D
Ver Producto
Semaphorin 4D (SEMA4D) Antibody
Semaphorin 4D Antibody is a Rabbit Polyclonal against Semaphorin 4D.
Ver Producto
Human Semaphorin 4D (SEMA4D) ELISA Kit
Human Semaphorin 4D (SEMA4D) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Semaphorin 4D (SEMA4D) concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Semaphorin 4D (SEMA4D)
Ver Producto