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Human Semaphorin 3A (SEMA3A) Protein (Active)
proveedor
Abbexareference
abx651439Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Semaphorin 3A (SEMA3A) Protein (Active) is an active protein from Human.
Background
Semaphorins constitute a large family of cell surface and secreted guidance molecules, categorized into eight classes due to their structural variations, They show a conserved sema domain in their N-terminal region. They primarily function as short-range inhibitory signals, particularly crucial in directing axons away from inappropriate areas, especially during neural system development. Plexins are the primary receptors for semaphorins, often working alongside neuropilins as co-receptors in receptor complexes. These molecules have various roles, and some classes of semaphorins (SEMA3,SEMA4,SEMA4,SEMA6 ,SEMA7)are found in vertebrates, contributing to processes like atherosclerosis by affecting endothelial function, leukocyte infiltration, monocyte-macrophage retention, platelet hyperreactivity, and neovascularization. Semaphorin-3A, encoded by the SEMA3A gene in humans, plays essential roles in the development of the olfactory system and the regulation of puberty. It induces the collapse and paralysis of neuronal growth cones, potentially acting as a ligand to guide specific growth cones through a motility-inhibiting mechanism. Semaphorin-3A exerts its effects by binding to the neuropilin-1/plexin-1 complex
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Semaphorin 3A (SEMA3A)
host
E. coli
conjugation
Unconjugated
form
Lyophilized
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
1 mg
size 5
5 mg
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SEMA3A
dry ice
No
availability
Shipped within 5-7 working days.
alias
HH16,SemD,COLL1,SEMA1,SEMAD,SEMAL,coll-1,Hsema-I,SEMAIII,Hsema-III,Semaphorin III,Semaphorin-3A
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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